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1

Advances in the treatment of chronic wounds: a patent review

van Koppen, Chris J, Hartmann, Rolf W

Journal:

Expert Opinion on Therapeutic Patents

Year:

2015

Language:

english

File:

PDF, 209 KB

english, 2015

2

Highly Potent 17β-HSD2 Inhibitors with a Promising Pharmacokinetic Profile for Targeted Osteoporosis Therapy

Siebenbuerger, Lorenz, Hernandez-Olmos, Victor, Abdelsamie, Ahmed S., Frotscher, Martin, van Koppen, Chris J., Marchais-Oberwinkler, Sandrine, Scheuer, Claudia, Laschke, Matthias W., Menger, Michael D

Journal:

Journal of Medicinal Chemistry

Year:

2018

Language:

english

File:

PDF, 934 KB

english, 2018

3

Profiling of anabolic androgenic steroids and selective androgen receptor modulators for interference with adrenal steroidogenesis

Patt, Melanie, Beck, Katharina R., Di Marco, Tobias, Jäger, Marie-Christin, González-Ruiz, Victor, Boccard, Julien, Rudaz, Serge, Hartmann, Rolf W., Salah, Mohamed, van Koppen, Chris J., Grill, Matthi

Journal:

Biochemical Pharmacology

Year:

2020

File:

PDF, 641 KB

2020

4

Thermal energy storage: G. Beckman and P. V. Gilli. Springer Verlag, ISBN 3-211-81764-6, 1984, X1 + 230 pp. Price DM 86

Chris van Koppen, Eindhoven

Journal:

Year:

1988

Language:

english

File:

PDF, 83 KB

english, 1988

5

Regulation of muscarinic acetylcholine receptor signaling

Chris J van Koppen, Björn Kaiser

Journal:

Pharmacology & Therapeutics

Year:

2003

Language:

english

File:

PDF, 413 KB

english, 2003

6

Molecular diversity of sphingolipid signalling

Dagmar Meyer zu Heringdorf, Chris J van Koppen, Karl H Jakobs

Journal:

Year:

1997

Language:

english

File:

PDF, 576 KB

english, 1997

7

Muscarinic receptors in the Mammalian Heart

Stefan Dhein, Chris J. van Koppen, Otto-Erich Brodde

Journal:

Pharmacological Research

Year:

2001

Language:

english

File:

PDF, 317 KB

english, 2001

8

Discovery of Selective Luteinizing Hormone Receptor Agonists Using the Bivalent Ligand Method

Kimberly M. Bonger, Richard J. B. H. N. van den Berg, Annemiek D. Knijnenburg, Laura H. Heitman, Chris J. van Koppen, Cornelis M. Timmers, Herman S. Overkleeft, Gijsbert A. van der Marel

Journal:

Year:

2009

Language:

english

File:

PDF, 306 KB

english, 2009

9

Synthesis and Pharmacological Evaluation of Dimeric Follicle-Stimulating Hormone Receptor Antagonists

Kimberly M. Bonger, Sascha Hoogendoorn, Chris J. van Koppen, Cornelis M. Timmers, Herman S. Overkleeft, Gijsbert A. van der Marel

Journal:

Year:

2009

Language:

english

File:

PDF, 265 KB

english, 2009

10

Distinct Internalization of M2 Muscarinic Acetylcholine Receptors Confers Selective and Long-Lasting Desensitization of Signaling to Phospholipase C

Riccarda Krudewig, Barbara Langer, Oliver Vögler, Nicole Markschies, Martin Erl, Karl H. Jakobs, Chris J. Van Koppen

Journal:

Journal of Neurochemistry

Year:

2000

Language:

english

File:

PDF, 180 KB

english, 2000

11

Regulation and functional roles of sphingosine kinases

Regina Alemany, Chris J. van Koppen, Kerstin Danneberg, Michael ter Braak, Dagmar Meyer zu Heringdorf

Journal:

Naunyn-Schmiedeberg's Archives of Pharmacology

Year:

2007

Language:

english

File:

PDF, 768 KB

english, 2007

12

A signaling-selective, nanomolar potent allosteric low molecular weight agonist for the human luteinizing hormone receptor

Chris J. van Koppen, Guido J. R. Zaman, C. Marco Timmers, Jan Kelder, Sietse Mosselman, Ruud van de Lagemaat, Martin J. Smit, Rob G. J. M. Hanssen

Journal:

Naunyn-Schmiedeberg's Archives of Pharmacology

Year:

2008

Language:

english

File:

PDF, 269 KB

english, 2008

13

The Cysteine Residue in the Carboxyl-Terminal Domain of the m2 Muscarinic Acetylcholine Receptor Is Not Required for Receptor-Mediated Inhibition of Adenylate Cyclase

Chris J. Van Koppen, Neil M. Nathanson

Journal:

Journal of Neurochemistry

Year:

1991

Language:

english

File:

PDF, 555 KB

english, 1991

14

Isolation, sequence and functional expression of the mouse m4 muscarinic acetylcholine receptor gene

Chris J. van Koppen, Wolfgang Lenz, Neil M. Nathanson

Journal:

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression

Year:

1993

Language:

english

File:

PDF, 319 KB

english, 1993

15

Cryopreserved cells facilitate cell-based drug discovery

Guido J.R. Zaman, Jeroen A.D.M. de Roos, Marion Blomenröhr, Chris J. van Koppen, Julia Oosterom

Journal:

Drug Discovery Today

Year:

2007

Language:

english

File:

PDF, 377 KB

english, 2007

16

Discrimination between plasma membrane and intracellular target sites of sphingosylphosphorylcholine

Dagmar Meyer zu Heringdorf, Nina Niederdräing, Eva Neumann, Rita Fröde, Holger Lass, Chris J. Van Koppen, Karl H. Jakobs

Journal:

European Journal of Pharmacology

Year:

1998

Language:

english

File:

PDF, 328 KB

english, 1998

17

Deletion analysis of the m4 muscarinic acetylcholine receptor : Molecular determinants for activation of but not coupling to the Gi guanine-nucleotide-binding regulatory protein regulate receptor internalization

Chris J. VAN KOPPEN, Alexandra SELL, Wolfgang LENZ, Karl H. JAKOBS

Journal:

Year:

1994

Language:

english

File:

PDF, 711 KB

english, 1994

18

The Role of Membrane Proximal Threonine Residues Conserved among Guanine-Nucleotide-Binding-Protein-Coupled Receptors in Internalization of the m4 Muscarinic Acetylcholine Receptor

Chris J. Van Koppen, Wolfgang Lenz, J. Pedro L. Nunes, Chunyi Zhang, Martina Schmidt, Karl H. Jakobs

Journal:

Year:

1995

Language:

english

File:

PDF, 636 KB

english, 1995

19

Enhanced cAMP Accumulation by the Human Thyrotropin Receptor Variant with the Pro52Thr Substitution in the Extracellular Domain

Ulrich Loos, Stefanie Hagner, Ulrich R. M. Bohr, Galina S. Bogatkewitsch, Karl H. Jakobs, Chris J. Van Koppen

Journal:

Year:

1995

Language:

english

File:

PDF, 478 KB

english, 1995

20

Mechanism of action of a nanomolar potent, allosteric antagonist of the thyroid-stimulating hormone receptor

Chris J van Koppen, Marcel E de Gooyer, Willem-Jan Karstens, Ralf Plate, Paolo GM Conti, Tanja AE van Achterberg, Monique GA van Amstel, Jolanda HGM Brands, Jesse Wat, Rob JW Berg, J Robert D Lane, An

Journal:

British Journal of Pharmacology

Year:

2012

Language:

english

File:

PDF, 1.10 MB

english, 2012

21

Simultaneous assay of muscarinic and β-adrenergic receptors using a double isotope technique

Chris J. van Koppen, Helene L.M. Siero, Jaap F.Rodrigues de Miranda, Arie J. Beld, Everardus J. Ariëns

Journal:

Biochemical and Biophysical Research Communications

Year:

1984

Language:

english

File:

PDF, 267 KB

english, 1984

22

Evidence for an endogenous factor involved in maintenance of pirenzepine high-affinity binding in rat brain stem

Chris J. van Koppen, Mordechai Sokolovsky

Journal:

Biochemical and Biophysical Research Communications

Year:

1988

Language:

english

File:

PDF, 344 KB

english, 1988

23

Chemical modification of rat cerebral cortex M1 muscarinic receptors: Role of histidyl residues in antagonist and agonist binding

Chris J. van Koppen, Mordechai Sokolovsky

Journal:

Biochemical and Biophysical Research Communications

Year:

1988

Language:

english

File:

PDF, 266 KB

english, 1988

24

Sphingosine kinase-mediated calcium signaling by muscarinic acetylcholine receptors

Chris J. van Koppen, Dagmar Meyer zu Heringdorf, Regina Alemany, Karl H. Jakobs

Journal:

Year:

2001

Language:

english

File:

PDF, 119 KB

english, 2001

25

Oligoproline helices as structurally defined scaffolds for oligomeric G protein-coupled receptor ligands

Bonger, Kimberly M., Kapoerchan, Varsha V., Grotenbreg, Gijsbert M., van Koppen, Chris J., Timmers, C. Marco, van der Marel, Gijsbert A., Overkleeft, Herman S.

Journal:

Organic & Biomolecular Chemistry

Year:

2010

Language:

english

File:

PDF, 223 KB

english, 2010

26

β-adrenoceptors in human tracheal smooth muscle: characteristics of binding and relaxation

Chris J. van Koppen, Marcel W. Hermanussen, Kiek N. Verrijp, Jaap F. Rodrigues de Miranda, Arie J. Beld, Jan-Willem J. Lammers, Cees A.M. van Ginneken

Journal:

Year:

1987

Language:

english

File:

PDF, 545 KB

english, 1987

27

Regulation of expression and function of muscarinic receptors

Beth A. Habecker, Kathleen M. Tietje, Chris J. van Koppen, Sharon A. Creason, Phyllis S. Goldman, Jacques C. Migeon, Lise A. Parenteau, Neil M. Nathanson

Journal:

Year:

1993

Language:

english

File:

PDF, 291 KB

english, 1993

28

Signaling of an allosteric, nanomolar potent, low molecular weight agonist for the follicle-stimulating hormone receptor

van Koppen, Chris J., Verbost, Pieter M., van de Lagemaat, Ruud, Karstens, Willem-Jan F., Loozen, Huub J.J., van Achterberg, Tanja A.E., van Amstel, Monique G.A., Brands, Jolanda H.G.M., van Doornmale

Journal:

Biochemical Pharmacology

Year:

2013

Language:

english

File:

PDF, 978 KB

english, 2013

29

Cloning and expression in Escherichia coli K-12 of the structural gene for outer membrane PhoE protein from Enterobacter cloacae

Verhoef, Cornelis, van Koppen, Chris, Overduin, Piet, Lugtenberg, Ben, Korteland, Jaap, Tommassen, Jan

Journal:

Year:

1984

Language:

english

File:

PDF, 980 KB

english, 1984

30

Autoradiographic visualization of muscarinic receptors in pulmonary nerves and ganglia

van Koppen, Chris J., Blankesteijn, W.Matthijs, Klaassen, AndréB.M., Rodrigues de Miranda, Jaap F., Beld, Arie J., van Ginneken, Cees A.M.

Journal:

Neuroscience Letters

Year:

1987

Language:

english

File:

PDF, 354 KB

english, 1987

31

Development of Selective LH Receptor Agonists by Heterodimerization with a FSH Receptor Antagonist

Bonger, Kimberly M., Hoogendoorn, Sascha, van Koppen, Chris J., Timmers, C. Marco, van der Marel, Gijsbert A., Overkleeft, Herman S.

Journal:

ACS Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 1.28 MB

english, 2011

32

Potent 11β-Hydroxylase Inhibitors with Inverse Metabolic Stability in Human Plasma and Hepatic S9 Fractions To Promote Wound Healing

Zhu, Weixing, Hu, Qingzhong, Hanke, Nina, van Koppen, Chris J., Hartmann, Rolf W.

Journal:

Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 497 KB

english, 2014

33

Reactions of Ground-State Ti + and V + with Propane: Factors That Govern C−H and C−C Bond Cleavage Product Branching Ratios

van Koppen, Petra A. M., Bowers, Michael T., Haynes, Chris L., Armentrout, P. B.

Journal:

Journal of the American Chemical Society

Year:

1998

Language:

english

File:

PDF, 144 KB

english, 1998

34

Thyrotropin Receptor-Stimulating Graves' Disease Immunoglobulins Induce Hyaluronan Synthesis by Differentiated Orbital Fibroblasts from Patients with Graves' Ophthalmopathy Not Only Via Cyclic Adenosine Monophosphate Signaling Pathways

van Zeijl, Clementine J.J., Fliers, Eric, van Koppen, Chris J., Surovtseva, Olga V., de Gooyer, Marcel E., Mourits, Maarten P., Wiersinga, Wilmar M., Miltenburg, André M.M., Boelen, Anita

Journal:

Year:

2011

Language:

english

File:

PDF, 292 KB

english, 2011

35

Effects of Thyrotropin and Thyrotropin-Receptor-Stimulating Graves' Disease Immunoglobulin G on Cyclic Adenosine Monophosphate and Hyaluronan Production in Nondifferentiated Orbital Fibroblasts of Graves' Ophthalmopathy Patients

van Zeijl, Clementine J.J., Fliers, Eric, van Koppen, Chris J., Surovtseva, Olga V., de Gooyer, Marcel E., Mourits, Maarten P., Wiersinga, Wilmar M., Miltenburg, André M.M., Boelen, Anita

Journal:

Year:

2010

Language:

english

File:

PDF, 557 KB

english, 2010

36

Complete Inhibition of rhTSH-, Graves' Disease IgG-, and M22-Induced cAMP Production in Differentiated Orbital Fibroblasts by a Low-Molecular-Weight TSHR Antagonist

van Zeijl, Clementine J. J., van Koppen, Chris J., Surovtseva, Olga V., de Gooyer, Marcel E., Plate, Ralf, Conti, Paolo, Karstens, Willem-Jan, Timmers, Marco, Saeed, Peerooz, Wiersinga, Wilmar M., Mil

Journal:

Journal of Clinical Endocrinology & Metabolism

Year:

2012

Language:

english

File:

PDF, 437 KB

english, 2012

37

Specificity of the Adrenal Steroid Receptor System in Rat Hippocampus*

VELDHUIS, H. DICK, VAN KOPPEN, CHRIS, VAN ITTERSUM, MARJANNE, DE KLOET, RONALD E.

Journal:

Year:

1982

Language:

english

File:

PDF, 1006 KB

english, 1982

38

Discovery of Triazole CYP11B2 Inhibitors with in Vivo Activity in Rhesus Monkeys

Hoyt, Scott B., Petrilli, Whitney, London, Clare, Liang, Gui-Bai, Tata, Jim, Hu, Qingzhong, Yin, Lina, van Koppen, Chris J., Hartmann, Rolf W., Struthers, Mary, Wisniewski, Tom, Ren, Ning, Bopp, Charl

Journal:

ACS Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 358 KB

english, 2015

39

Towards the evaluation in an animal disease model: Fluorinated 17β-HSD1 inhibitors showing strong activity towards both the human and the rat enzyme

Abdelsamie, Ahmed S., Bey, Emmanuel, Gargano, Emanuele M., van Koppen, Chris J., Empting, Martin, Frotscher, Martin

Journal:

European Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 1.20 MB

english, 2015

40

Multiple Pathways of Dynamin-regulated G protein-coupled Receptor Internalization

van Koppen, Chris J.

Journal:

Biochemical Society Transactions

Year:

2001

Language:

english

File:

PDF, 113 KB

english, 2001

41

First Structure-Activity Relationship of 17β-Hydroxysteroid Dehydrogenase Type 14 Nonsteroidal Inhibitors and Crystal Structures in Complex with the Enzyme

Braun, Florian, Bertoletti, Nicole, Möller, Gabriele, Adamski, Jerzy, Steinmetzer, Torsten, Salah, Mohamed, Abdelsamie, Ahmed Saad, van Koppen, Chris J, Heine, Andreas, Klebe, Gerhard, Marchais-Oberwi

Journal:

Journal of Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 20.66 MB

english, 2016

42

Treatment of estrogen-dependent diseases: Design, synthesis and profiling of a selective 17β-HSD1 inhibitor with sub-nanomolar IC50 for a proof-of-principle study

Abdelsamie, Ahmed S., van Koppen, Chris J., Bey, Emmanuel, Salah, Mohamed, Börger, Carsten, Siebenbürger, Lorenz, Laschke, Matthias W., Menger, Michael D., Frotscher, Martin

Journal:

European Journal of Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 1.72 MB

english, 2016

43

Lead optimization generates CYP11B1 inhibitors of pyridylmethyl isoxazole type with improved pharmacological profile for the treatment of Cushing’s disease

Emmerich, Juliette, van Koppen, Chris J, Burkhart, Jens L., Hu, Qingzhong, Siebenbürger, Lorenz, Boerger, Carsten, Scheuer, Claudia, Laschke, Mathias W., Menger, Michael D., Hartmann, Rolf W.

Journal:

Journal of Medicinal Chemistry

Year:

2017

Language:

english

File:

PDF, 1.16 MB

english, 2017

44

A Child with Local Lipohypertrophy following Recombinant Human Growth Hormone Administration

Koppen, Ilan J. N., Bakx, Roel, de Kruiff, Chris C., van Trotsenburg, A. S. Paul

Journal:

Case Reports in Pediatrics

Year:

2016

Language:

english

File:

PDF, 1.29 MB

english, 2016

45

Development of potential preclinical candidates with promising in vitro ADME profile for the inhibition of type 1 and type 2 17β-Hydroxysteroid dehydrogenases: Design, synthesis, and biological evaluation

Abdelsamie, Ahmed S., Salah, Mohamed, Siebenbürger, Lorenz, Hamed, Mostafa M., Börger, Carsten, van Koppen, Chris J., Frotscher, Martin, Hartmann, Rolf W.

Journal:

European Journal of Medicinal Chemistry

Year:

2019

Language:

english

File:

PDF, 953 KB

english, 2019

46

Effects of 17β-HSD2 inhibition in bones on osteoporosis based on an animal rat model

Müller, Sebastian T., Pählig, Sophie, Merabet, Ahmed, Abdelsamie, Ahmed S., van Koppen, Chris J., Marchais-Oberwinkler, Sandrine, Hartmann, Rolf W., Zierau, Oliver, Vollmer, Günter

Journal:

The Journal of Steroid Biochemistry and Molecular Biology

Year:

2019

Language:

english

File:

PDF, 755 KB

english, 2019

47

Fluorescent small-molecule agonists as follicle-stimulating hormone receptor imaging tools

Hoogendoorn, Sascha, van Puijvelde, Gijs H. M., van der Marel, Gijs A., van Koppen, Chris J., Timmers, C. Marco, Overkleeft, Herman S.

Journal:

RSC Chemical Biology

Year:

2020

File:

PDF, 3.91 MB

2020